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KMID : 1094720120170061190
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Biotechnology and Bioprocess Engineering
2012 Volume.17 No. 6 p.1190 ~ p.1195
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Synthesis and self-assembly of a DNA-conjugated poly(propylene glycol) derivative
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Um Soong-Ho
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Abstract
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Due to several characteristic features of DNA (e.g., genetic coding transfer and nanoscaled accuracy or so), DNA based compounds have been recently highlighted in a variety of research fields, including physics, chemistry, engineering or so. To date, they have been expanded into a hybrid form conjugated with conventional polymer groups. Such synthetic hybrid conjugates can be organized into multi-dimensional nanoor micro-structures; rod, sheet, and spherical shaped nanomaterials [1]. In this study, we showed a novel block copolymer composed of DNA and poly(propylene glycol) (PPG) (designated as DNA-b-PPG) for the self-assembled construction into three-dimensional vesicular structures.
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KEYWORD
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DNA-b-PPG, self-assembled vesicle
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